Stem Cell Niche

Niche here refers where stem cells reside & get activated to differentiate and proliferate. Niche Stem Cells show a strong interaction in keeping dynamic system (bone marrow niche) functional. They are the source of secreted or cell surface factor which includes member of Notch, Wnt, Fibroblast growth factor (FGR), Transforming Growth Factor (TGF)-beta, Stem Cell Factor (SCF) and Chemokine families-controls stem cell renewal, maintenance & survival.